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In an early setback for Wormwood, The Patient becomes a Christian. Screwtape isn’t happy about this, but he reassures his nephew that all is not lost just yet.

The novice demon Wormwood is assigned a human (“the Patient”) to keep “out of the Enemy's clutches”. Wormwood feels the best way to accomplish this is to control what the Patient reads and the company he keeps. His uncle Screwtape offers guidance from below.